Peptide Variant Comparison

The peptide variant comparison (PVC) tool will take a paired list of wild-type and mutant peptides, and run the class I binding tools over each peptide.

Input Sequences

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The PVC tool takes a list of paired wild-type and mutant peptide sequences as input.

Example:

FLYNPLTRV	FLYNLLTRV
MLGERLFPL	MLGEQLFPL
FLDEFMEAV	FLDEFMEGV

Delimiters

The paired wild-type and mutant peptides should be delimited by either a tab or space. The delimiter , or CSV file is not compatible with the PVC tool.

Parameter selection

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The parameter selection UI is identical to T Cell Prediction - Class I

• MHC alleles

  Please refer to Getting Started > Prediction Parameters > MHC alleles for how MHC allele control section works.

  Unsupported Alleles

  If a target allele is unsearchable, it is most likely not curated yet.

• Prediction models

  Please refer to Getting Started > Prediction Parameters > Prediction models for how the prediction models control section works.

  As for the types of models that we provide, please reference Available Tools > T cell class I > MHC-binding predictions > Methods.

Results

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Please refer to Getting Started > Prediction Parameters > Tabular Results for controls of the result table.

Interpretation

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